Does moxibustion work? An overview of systematic reviews (2024)

Abstract

Background

Several systematic reviews (SRs) have assessed the effectiveness of moxibustion for a range of conditions, often with contradictory conclusions. Our aim was to provide a critical evaluation and summary of these data.

Methods

Electronic searches were conducted to locate all SRs of moxibustion for any condition. Data were extracted by two authors according to predefined criteria.

Results

Ten SRs met our inclusion criteria, which related to the following conditions: cancer, ulcerative colitis, stroke rehabilitation, constipation, hypertension, pain conditions and breech presentation. Their conclusions were contradictory in several instances. Relatively clear evidence emerged to suggest that moxibustion is effective for breech presentation.

Conclusions

Based on evidence from the currently available SRs, the effectiveness of moxibustion has been demonstrated for several conditions; however, due to the poor quality of the primary studies, there remains considerable uncertainty.

Background

Moxibustion is an East Asian therapeutic method that uses the heat generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points [1]. According to the theory of traditional medicine, heat is usually applied to acupuncture points during moxibustion to cure diseases by regulating the function of meridians and visceral organs. A possible explanation for how moxibustion works is that the heat stimulates acupuncture points, which increases qi circulation and relieves qi stagnation, leading to an improved disease state [2].

Acupuncture stimulation, which involves thrusting or twisting needles, results in various biochemical reactions that can have effects throughout the body. Unlike acupuncture, moxibustion uses heat stimulation at various temperature levels, ranging from mild skin warming to tissue damage from burning. This heat stimulation can yield inflammatory responses and induce vascular changes [2].

Although moxibustion is often used as a symptomatic treatment for a wide range of conditions in clinical practice, e.g., arthritis, gastrointestinal problems, gynaecological complaints and stroke rehabilitation, its clinical effectiveness remains uncertain [3-5], and many experts doubt its biological plausibility. Numerous clinical trials have emerged; however, their results are contradictory. Thus, SRs assessing the summary of this evidence may bring clarification. To date, several such articles have been published. Unfortunately, however, the conclusions drawn in these publications are also conflicting.

This overview is aimed at summarising and critically evaluating all SRs on moxibustion as a symptomatic treatment for any condition. Our ultimate goal is to provide clinicians with clearer guidance regarding the value of this therapy.

Methods

The following databases were searched on July 22, 2010 without language restrictions: Medline, EMBASE, AMED, CINHAL, the Cochrane Library, six Korean Medical Databases (Korean Studies Information, DBPIA, Korea Institute of Science and Technology Information, Korea Education and Research Information Service, KoreaMed and Korean National Assembly Library) and Chinese Databases (CNKI). In addition, our extensive departmental files were searched by hand. The keywords used in the search were (systematic review OR meta-analysis) AND (moxa OR moxibustion). Articles were included if they related to a formal SR or meta-analysis on any type of moxibustion as a treatment for any type of condition. Reviews, comments and overviews without a systematic methods section were excluded.

To be included, the SR had to be concerned specifically with the effectiveness of moxibustion and include evidence from at least two controlled clinical trials. SRs evaluating moxibustion together with acupuncture without separate evaluation of each approach were excluded.

Key data were extracted independently by two authors (MSL & JWK) according to predefined criteria, including conditions, number of primary studies, methodological quality of the primary studies, conclusion of each SR, and data related with searching. Disagreements were resolved by discussion between the authors. Judgement about the quality of the primary studies was adopted from the respective SRs. The Overview Quality Assessment Questionnaire (OQAQ) was used to evaluate the methodological quality of all included SRs [6]. In the OQAQ, the score ranges from 1 to 7. A score of 3 or less was considered as indicative of major flaws, whereas a score of 5 or more suggested only minor flaws. The two authors did these assessments independently, and discrepancies were settled by discussion.

Results

Our searches generated 99 hits, and 10 articles met our inclusion criteria (Figure 1, Table 1) [3,7-15]. These studies included a wide range of conditions, including cancer [11], ulcerative colitis [10], stroke rehabilitation [12], several pain conditions [13], constipation [14], hypertension [15] and breech presentation [7-9]. Approximately half of the SRs arrived at a positive conclusion [8,9,11-13]. Most of the SRs were of good quality, but all had to rely on poor quality primary studies.

Figure 1.

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Table 1.

Systematic reviews on moxibustion for health care

First author
Year (Ref)
ConditionNo. of primary studiesMethodological quality of primary studiesQuality of SR
OQAQ*
Meta-analysisConclusion (quote)Authors' result
Kim
(2010) [3]
Various conditions48 RCTsPoor5Ulcerative colitis
1) Moxa vs. drug (2 RCTs), RR, 2.20, 95% CIs,1.37 to 3.52, P = 0.001, I2 = 0%
2) Moxa vs. wait control (2 RCTs), RR, 1.19, 95CIs, 0.88 to 1.60, P = 0.26, I2 = 40%
3) Moxa plus postual care vs. postual care, RR, 1.51, 95%CIs, 1.10 to 2.08, P = 0.01, I2 = 86%
Our results did not support the effectiveness of moxibustion in specific disease+/-
Coyle
(2005) [7]
Breech presentation3 RCTsPoor7NoneThere is insufficient evidence to support ...+/-
Li
(2009) [8]
Breech presentation17(10 RCTs and 7 CCTs)Poor71) Moxa vs. no treatment (3 RCTs), RR, 135, 95%CIs, 1.20 to 1.51, P < 0.00001
2) Moxa vs. knee-chest position (3 RCTs), RR, 1.30, 95%CIs, 0.95 to 1.79, P = 0.1
3) Moxa plus other treatment vs. other treatment (2 RCTs), RR, 1.36, 95%CIs, 1.21 to 1.54, P < 0.00001
...tend to be effective...+
Vas
(2009) [9]
Breech presentation7 RCTsVariable7Moxa vs. control (6 studies), RR, 1.36, 95% CIs, 1.17 to 1.58, P < 0.0001Moxibustion at ...BL67 has been shown to produce a positive effect...+
Lee
(2010) [10]
Ulcerative colitis5 RCTsPoor7Moxa vs. drug (5 RCTs), RR, 1.24, 95% CIs, 1.11 to 1.38, P < 0.0001, I2 = 16%Current evidence is insufficient ...+/-
Lee
(2010) [11]
Cancer5 RCTsPoor6Moxa plus chemotherapy vs. chemotherapy
1) Response rate (4 RCTs), RR, 1.04, 95% CIs, 0.94 to 1.15, P = 0.43, I2 = 26%
2) Side effects (2 RCTs), RR, 0.38, 95% CIs, 0.22 to 0.65, P = 0.0005, I2 = 0%
The evidence is limited to suggest moxibustion is an effective supportive cancer care in nausea and vomiting.+
Lee
(2010) [12]
Stroke rehabilitation9 RCTsPoor5Moxa vs. standard care
1) Motor function (3RCTs), SMD, 0.72, 95% CIs, 0.37 to 1.08, P < 0.0001, I2 = 5%
2) Activities of daily living (3 RCTs), SMD, 0.51, 95%CIs,
-0.08 to 1.10, P = 0.09, I2 = 62%
...found limited effectiveness of moxibustion as an adjunct to standard care...+
Lee
(2010) [13]
Pain conditions4 RCTsPoor7Osteoarthritis: Moxa vs. drug (2 RCTs), RR, 1.11, 95%CIs, 1.02 to 1.21, P = 0.02, I2 = 3%...limited evidence ... in the management of osteoarthritis of the knee and other pain condition+
Lee
(2010) [14]
Constipation3 RCTsPoor3None... evidence is scarce and insufficient to suggest...+/-
Kim
(2010) [15]
Hypertension4 RCTsPoor5NoneThere is insufficient...+/-

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This was relied on the original authors' judgment;* Overview quality assessment questionnaire (OQAQ). The overall score is from 1 to 7. OQAQ ≤ 3: having extensive or major flaws; 5 ≤ OQAQ: having minor or minimal flaws. +: overall positive; -: fail to show effectiveness; +/-: unclear. SR: systematic review; RCT: randomized controlled trial; CCT: non-randomized controlled trial.

For one particular condition, breech presentation, three SRs were available [7-9]. Two showed clearly positive results [8,9], whereas the other cast doubt on the clinical relevance of the effect due to the small number of included trials [7]. For the studies regarding cancer (10), stroke (11) and pain (12), the conclusions were cautiously positive. Equivocal conclusions emerged from the SRs on ulcerative colitis [10], constipation [14] and hypertension [15]. One SR evaluated the effects of moxibustion on various conditions and failed to arrive at a clearly positive conclusion [3].

Discussion

Our overview shows that several SRs on moxibustion have been published. The fact that most of them were recent indicates that the scientific interest in moxibustion is growing. Even though most of the reviews are of high quality [3,7-15], they are based on few clinical trials that were not well controlled. Several SRs have arrived at positive overall conclusions; however, some of the studies regarding breech presentation contradict each other [7-9]. This can be explained by the time difference amongst the three SRs. The more up-to-date SR includes four to seven more rigorous and positive studies than the first SR [8,9]. Thus, the sum of the best evidence to date seems to suggest that moxibustion is effective for breech presentation.

Positive conclusions were also reached for the treatment for nausea and vomiting in cancer patients [11], stroke rehabilitation [12] and pain conditions [13]. Unfortunately, these SRs were based mostly on poor quality primary studies. Thus, considerable uncertainty about the value of moxibustion for these indications persists.

Three SRs relating to ulcerative colitis [10], constipation [14] and hypertension [15] were of poor quality, and all relied on a small number of flawed studies. It therefore seems fair to say that the value of moxibustion is not well-documented for any of these conditions.

In essence, this means that the effectiveness of moxibustion is currently not well-documented for several conditions, which is in sharp contrast to the many claims made by the proponents of this therapeutic modality, including those practicing traditional Chinese medicine or complementary and alternative medicine.

SRs on moxibustion have stated their studies to be limited by the often poor quality of the primary data. Our analysis confirms this view. Many of the primary moxibustion trials originate from China (data not shown); Vickers et al. demonstrated that virtually 100% of Chinese acupuncture trials are positive [16], which seems to be equally applied to moxibustion, an acupuncture-like intervention. This casts considerable doubt on the reliability of these studies. Collectively, these facts limit the conclusiveness of SRs on moxibustion, thereby leaving a level of uncertainty. SRs have been criticised for being often unable to provide specific guidance. Yet, even if uncertainty prevails, SRs have the important function of mapping areas of doubt. Thus, as pointed out above, our overview highlights areas of research in which investment in further clinical trials would be fruitful.

Thus our overview of SRs suggests that future moxibusition-research should consider all necessary measure to minimize bias including development of possible sham or placebo moxibustion. We recommend to follow the CONSORT guidelines when designing clinical trials of moxibustion [17]. Similarly, SRs of moxibustion should abide by the PRISMA guidelines to reduce the risk of bias [18].

Our overview has several important limitations. Even though our search strategy was thorough, we cannot completely exclude the notion that relevant articles were missed. By evaluating systematic reviews rather than clinical trials, important details of the primary studies may have been lost. Most importantly, the poor quality of the primary data and the systematic reviews is regrettable. Collectively, these limitations limit the conclusiveness of our findings.

In conclusion, this overview of SRs suggests that moxibustion is effective for correcting breech presentation, whereas for other conditions, the evidence does not reach a firm conclusion because of several limitations. All SRs are, however, based on studies with a high risk of bias. Therefore, considerable uncertainty remains about the therapeutic value of moxibustion.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

MSL, JWK and EE designed the review, performed searches, appraised and selected trials, extracted data, contacted authors for additional data, carried out analyses and interpretations of the data, and drafted this report. EE reviewed and critiqued the review protocol and this report and assisted in designing the review. All authors read and approved the final manuscript.

Contributor Information

Myeong Soo Lee, Email: drmslee@gmail.com.

Jung Won Kang, Email: doctorkang@naver.com.

Edzard Ernst, Email: edzard.ernst@pms.ac.uk.

Acknowledgements

Funding to pay the Open Access publication charge for this article was provided by KIOM (K10251). M.S. Lee was supported by KIOM (K10251).

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Does moxibustion work? An overview of systematic reviews (2024)

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